Requirement of the ETS domain transcription factor D-ELG for egg chamber patterning and development during Drosophila oogenesis

Oncogene. 1995 Sep 21;11(6):1033-40.

Abstract

The D-elg gene encodes an ETS domain transcription factor that functions in Drosophila oogenesis. D-elg belongs to a small group of genes that are required for the formation of both the anteroposterior and dorsoventral axes of the egg chamber. During oogenesis in D-elg mutant females, the spatial localization of oskar and gurken mRNAs in the oocyte is disrupted and a follicle cell enhancer trap marker identifies dorsoventral polarity defects. Also, specialized follicle cells, called border cells, fail to migrate from their anterior location to a position adjacent to the developing oocyte. Consistent with these phenotypes, D-elg shows genetic interactions with two genes required for normal egg chamber differentiation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Movement
  • Drosophila / physiology*
  • Drosophila Proteins*
  • Female
  • Homeodomain Proteins*
  • Insect Hormones / genetics
  • Mutation
  • Oogenesis*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • RNA, Messenger / analysis
  • Trans-Activators*

Substances

  • Drosophila Proteins
  • Homeodomain Proteins
  • Insect Hormones
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Trans-Activators
  • bcd protein, Drosophila
  • Ets97D protein, Drosophila