Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases

Res Microbiol. 1995 May;146(4):271-8. doi: 10.1016/0923-2508(96)81050-3.


Thirty-eight ATP-binding cassette (ABC) protein constituents of bacterial extracytoplasmic receptor-dependent nutrient uptake systems, including one homologous chloroplast protein were analysed for sequence conservation and phylogenetic relatedness. The proteins were generally found to cluster in accordance with the clustering patterns previously observed for the extracytoplasmic receptors and the transmembrane channel-forming constituents of these permeases. The results suggest that these transport systems evolved from a single primordial system with minimal shuffling of the three dissimilar protein constituents of the systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / classification*
  • ATP-Binding Cassette Transporters / genetics
  • Amino Acid Sequence
  • Gram-Negative Bacteria / chemistry*
  • Gram-Negative Bacteria / enzymology
  • Gram-Negative Bacteria / genetics
  • Gram-Positive Bacteria / chemistry*
  • Gram-Positive Bacteria / enzymology
  • Gram-Positive Bacteria / genetics
  • In Vitro Techniques
  • Membrane Transport Proteins / chemistry*
  • Molecular Sequence Data
  • Phylogeny


  • ATP-Binding Cassette Transporters
  • Membrane Transport Proteins