Neuronal Ca2+ stores: activation and function

Trends Neurosci. 1995 Jul;18(7):299-306. doi: 10.1016/0166-2236(95)93919-o.


The intracellular concentration of free Ca2+ ([Ca2+]i) displays complex fluctuations in response to a variety of stimuli, and acts as a pluripotent signal for many neuronal functions. It is well established that various 'metabotropic' neurotransmitter receptors can mediate the mobilization of Ca2+ stores via actions of inositol-polyphosphate second messengers, and more recent evidence suggests that 'ionotropic' receptor-mediated Ca2+ signals in neurones might also involve release of Ca2+ from intracellular stores. These two mechanisms of release of Ca2+ enable considerable temporal and spatial complexity of increases in the [Ca2+]i via multiple interactions at the level of intracellular-receptor activation. The complexity of Ca2+ signalling that is elicited via these interconnecting pathways might underlie mechanisms that are central to information transfer and integration within neuronal compartments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biotransformation / physiology
  • Calcium / metabolism*
  • Calcium / physiology*
  • Humans
  • Neurons / metabolism*
  • Neurons / physiology*


  • Calcium