Isolation and biological activities of signal transduction inhibitors from microorganisms and plants

Adv Enzyme Regul. 1995;35:43-53. doi: 10.1016/0065-2571(94)00018-x.

Abstract

Microorganisms and plants are treasuries of secondary metabolites having unique structures and biological activities. We have isolated inhibitors of cellular signal transduction from them. Phosphatidylinositol turnover inhibitors include inostamycin, piericidins and echiguanines. Erbstatin and lavendustin A were isolated as tyrosine kinase inhibitors, and dephostatin was isolated as a tyrosine phosphatase inhibitor. Recently, we have isolated a new vinca alkaloid having anti-ras activity. These signal transduction inhibitors will be useful for mechanistic studies and suppression of cancer.

Publication types

  • Review

MeSH terms

  • 1-Phosphatidylinositol 4-Kinase
  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology*
  • Fungi / chemistry*
  • Molecular Structure
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositols / metabolism
  • Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Plants / chemistry*
  • Protein Tyrosine Phosphatases / antagonists & inhibitors
  • Protein Tyrosine Phosphatases / metabolism
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / metabolism
  • Signal Transduction / drug effects*
  • Streptomyces / chemistry*
  • Transferases (Other Substituted Phosphate Groups) / antagonists & inhibitors
  • ras Proteins / antagonists & inhibitors

Substances

  • Enzyme Inhibitors
  • Phosphatidylinositols
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • 1-Phosphatidylinositol 4-Kinase
  • Protein-Tyrosine Kinases
  • Transferases (Other Substituted Phosphate Groups)
  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
  • Protein Tyrosine Phosphatases
  • ras Proteins