Clinical implications of insulin resistance syndromes

Am J Med. 1995 Oct;99(4):420-6. doi: 10.1016/s0002-9343(99)80191-0.


Epidemiologic studies have shown an association between higher insulin levels and coronary artery disease, and metabolic studies have associated insulin resistance and compensatory hyperinsulinemia with hypertension, obesity, and lipid disorders. This review focuses on the clinical implications (rather than the metabolic pathogeneses) of these associations and how practicing physicians should manage patients with insulin resistance.

Publication types

  • Review

MeSH terms

  • Coronary Disease / physiopathology
  • Female
  • Humans
  • Hyperlipidemias / physiopathology
  • Hypertension / physiopathology
  • Insulin Resistance / physiology*
  • Obesity / physiopathology
  • Polycystic Ovary Syndrome / physiopathology