Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes

Am J Med Genet. 1995 Jun 19;60(3):252-60. doi: 10.1002/ajmg.1320600316.


Using a systematically ascertained sample of 57 families, each having 2 or more members with a consensus diagnosis of schizophrenia (DSM-III-R criteria), we have carried out linkage studies of 520 loci, covering approximately 70% of the genome for susceptibility loci for schizophrenia. A two-stage strategy based on lod score thresholds from simulation studies of our sample identified regions for further exploration. In each region, a dense map of highly informative dinucleotide repeat polymorphisms (heterozygosity greater than .70) was analyzed using dominant, recessive, and "affected only" models and nonparametric sib pair identity-by-descent methods. For one region, 8p22-p21, affected sib-pair analyses gave a P value = .0001, corresponding to a lod score approximately equal to 3.00. For 8p22-p21, the maximum two-point lod score occurred using the "affected only" recessive model (ZMAX = 2.35; theta M = theta F); allowing for a constant sex difference in recombination fractions found in reference pedigrees, ZMAX = 2.78 (theta M/theta F = 3). For a second region, 3p26-p24, the maximum two-point lod score was 2.34 ("affected only" dominant model), and the affected sib-pair P value was .01. These two regions are worthy of further exploration as potential sites of susceptibility genes for schizophrenia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biomarkers
  • Chromosome Mapping
  • Chromosomes, Human, Pair 3*
  • Chromosomes, Human, Pair 8*
  • Family
  • Female
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Humans
  • Lod Score
  • Male
  • Schizophrenia / genetics*


  • Biomarkers