Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial

Am J Obstet Gynecol. 1995 Sep;173(3 Pt 1):881-4. doi: 10.1016/0002-9378(95)90359-3.


Objective: Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy.

Study design: During an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment.

Results: There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552).

Conclusion: Pyridoxine is effective in relieving the severity of nausea in early pregnancy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiemetics / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Nausea / drug therapy*
  • Placebos
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Pyridoxine / therapeutic use*
  • Vomiting / drug therapy*


  • Antiemetics
  • Placebos
  • Pyridoxine