Quantitative bone scintigraphy in the management of monostotic Paget's disease of bone

Arthritis Rheum. 1995 Oct;38(10):1506-12. doi: 10.1002/art.1780381018.


Objective: To assess the use of quantitative bone scanning (QBS) in the monitoring of patients with intravenous pamidronate-treated symptomatic monostotic Paget's disease of bone in whom biochemical markers of bone turnover are relatively normal.

Methods: QBS was performed in 9 patients and the results were expressed as a ratio, obtained by comparing isotope uptake at an affected and a control (unaffected) site.

Results: Serum alkaline phosphatase levels were normal in 7 of the 9 patients and changed minimally with treatment. The median QBS ratio was 2.72 (range 1.69-24.6) at baseline and 1.49 (range 0.63-4.18) posttreatment (P = 0.008). The median symptom score decreased with treatment, but QBS ratios provided the only objective measure of disease activity by which response to pamidronate therapy could be judged.

Conclusion: QBS may be a useful technique for evaluating the effects of treatment in patients with Paget's disease of bone.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Remodeling / physiology*
  • Diphosphonates / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteitis Deformans / diagnostic imaging*
  • Osteitis Deformans / drug therapy*
  • Osteitis Deformans / physiopathology
  • Pamidronate
  • Radionuclide Imaging
  • Severity of Illness Index


  • Diphosphonates
  • Pamidronate