Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance

Immunol Today. 1995 Oct;16(10):487-94. doi: 10.1016/0167-5699(95)80033-6.


Malignant transformation of melanocytes may be associated with changes in the expression of major histocompatibility complex (MHC) HLA class I antigens. Interest in the characterization of abnormalities in the expression of MHC class I by melanoma cells has been rekindled by the current emphasis on the application of T-cell-based immunotherapy to melanoma. Here, Soldano Ferrone and Francesco Marincola review defects in class I expression as described in melanoma cells, as well as the molecular mechanisms, functional significance and clinical implications of such defects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Down-Regulation
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Melanoma / immunology*


  • Histocompatibility Antigens Class I