Genetic mechanisms of early neurogenesis in Drosophila melanogaster

Mol Neurobiol. Apr-Jun 1995;10(2-3):75-89. doi: 10.1007/BF02740668.

Abstract

The neurogenic ectoderm of Drosophila melanogaster consists of the ventral neuroectoderm and the procephalic neuroectoderm. It is hypothesized that epidermal and central neural progenitor cells separate from each other in three steps: conference on the neuroectodermal cells the capability of producing neural or epidermal progenies, separation of the two classes of progenitor cells, and specification of particular types of neuroblasts and epidermoblasts. Separation of neuroblasts and epidermoblasts is controlled by proneural and neurogenic genes. Delta and Notch serve as mediators of direct protein-protein interactions. E(SPL)-C inhibits neurogenesis, creating epidermal cells. The achaete-scute complex (AS-C) controls the commitment of nonoverlapping populations of neuroblasts and leads the development of neuroectodermal cells as neuroblasts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Differentiation
  • Cell Lineage
  • Central Nervous System / embryology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Drosophila Proteins*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics*
  • Ectoderm / cytology*
  • Ectoderm / metabolism
  • Gene Expression Regulation, Developmental*
  • Genes, Insect*
  • Hyperplasia
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Morphogenesis / genetics
  • Receptors, Notch
  • Sense Organs / embryology
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch
  • Transcription Factors
  • ac protein, Drosophila
  • delta protein
  • sc protein, Drosophila