Antimicrobial effects of tea-tree oil and its major components on Staphylococcus aureus, Staph. epidermidis and Propionibacterium acnes

Lett Appl Microbiol. 1995 Oct;21(4):242-5. doi: 10.1111/j.1472-765x.1995.tb01051.x.

Abstract

Major components of two tea-tree oil samples were identified using thin layer and gas-liquid chromatography (TLC and GLC). Using a TLC-bioautographic technique, the tea-tree oils, terpinen-4-ol, alpha-terpineol and alpha-pinene were found to be active against Staphylococcus aureus, Staph. epidermidis and Propionibacterium acnes whereas cineole was inactive against these organisms. The MIC values of the three active compounds increased in the order alpha-terpineol < terpinen-4-ol < alpha-pinene for all three micro-organisms. MIC values of the tea-tree oils and terpinen-4-ol were lower for P. acnes than for the two staphylococci. This study supports the use of tea-tree oil in the treatment of acne, and demonstrates that terpinen-4-ol is not the sole active constituent of the oil.

MeSH terms

  • Anti-Infective Agents, Local / chemistry
  • Anti-Infective Agents, Local / pharmacology*
  • Microbial Sensitivity Tests
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*
  • Plant Oils / chemistry
  • Plant Oils / pharmacology*
  • Propionibacterium acnes / drug effects*
  • Propionibacterium acnes / growth & development
  • Species Specificity
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / growth & development
  • Staphylococcus epidermidis / drug effects*
  • Staphylococcus epidermidis / growth & development
  • Tea Tree Oil

Substances

  • Anti-Infective Agents, Local
  • Oils, Volatile
  • Plant Oils
  • Tea Tree Oil