HLA antigens in ulcerative colitis and primary sclerosing cholangitis

APMIS. Jul-Aug 1995;103(7-8):519-24. doi: 10.1111/j.1699-0463.1995.tb01400.x.

Abstract

The aims of this study were to find out whether the alleles of the HLA class I or II region are associated with susceptibility to ulcerative colitis, and to show whether there is a difference or similarity in HLA associations between primary sclerosing cholangitis and ulcerative colitis. HLA-A, B, C and DR antigens were studied using the standard lymphocyte microcytotoxicity test in 24 Finnish patients with primary sclerosing cholangitis, 77 patients with ulcerative colitis, and 106 controls. HLA-B8 (54%) and DR3 (60%) were associated with primary sclerosing cholangitis. HLA-DR1 (46%) and DR6 (20%) seemed more common in ulcerative colitis than in controls. A positive association with Cw7 was common to both ulcerative colitis (25%) and primary sclerosing cholangitis (33%). Our results indicate that ulcerative colitis is more heterogeneous than primary sclerosing cholangitis in its HLA-DR associations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alleles
  • Child
  • Cholangitis, Sclerosing / immunology*
  • Colitis, Ulcerative / immunology*
  • Female
  • HLA Antigens / analysis*
  • HLA Antigens / genetics
  • Humans
  • Male
  • Middle Aged

Substances

  • HLA Antigens