Differentiation of malignant neuroblastoma cells: evidence for a mitochondrial role

Cell Biol Int Rep. 1977 Sep;1(5):435-8. doi: 10.1016/0309-1651(77)90077-7.

Abstract

Morphological differentiation has been induced in vitro in mouse neuroblastoma cells by quinidine, dinitrophenol and dicoumarol. These agents are known to release calcium from mitochondria. Drugs acting in this way might be exploited in cancer therapy.

MeSH terms

  • Calcium / metabolism
  • Cell Differentiation / drug effects*
  • Cell Division / drug effects
  • Cell Line
  • Dicumarol / pharmacology
  • Dinitrophenols / pharmacology
  • Mitochondria / metabolism*
  • Neuroblastoma / drug therapy
  • Neuroblastoma / pathology
  • Quinidine / pharmacology

Substances

  • Dinitrophenols
  • Dicumarol
  • Quinidine
  • Calcium