Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1

Mech Dev. 1995 Jul;52(1):3-8. doi: 10.1016/0925-4773(95)00380-j.


In the Drosophila embryo, activation of wingless and engrailed in the parasegment requires paired, a member of the Pax family of transcription factors. We have explored the possible conservation of this regulatory hierarchy in the developing mouse brain. We find that Pax-2 is expressed prior to somite formation in the presumptive mid/hindbrain region. Shortly thereafter, Wnt-1 (the wingless orthologue) and Engrailed-1 are expressed in overlapping regions within the Pax-2 domain. Pax-5 expression commences later, at the 3-somite stage. Thus, the spatial and temporal expression of Pax-2 is consistent with a possible regulatory role in the activation of Wnt-1 and En-1.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / embryology*
  • Brain / metabolism
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / genetics
  • Embryonic and Fetal Development
  • Female
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins / biosynthesis*
  • Homeodomain Proteins / genetics
  • Mice
  • PAX2 Transcription Factor
  • Pregnancy
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics
  • Transcription Factors / biosynthesis*
  • Transcription Factors / genetics
  • Wnt Proteins
  • Wnt1 Protein
  • Zebrafish Proteins*


  • DNA-Binding Proteins
  • En1 protein, mouse
  • Homeodomain Proteins
  • PAX2 Transcription Factor
  • Pax2 protein, mouse
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Wnt Proteins
  • Wnt1 Protein
  • Wnt1 protein, mouse
  • Zebrafish Proteins