The role of dietary factors and chemoprevention in gastrointestinal malignancy

Curr Opin Oncol. 1995 Jul;7(4):377-80. doi: 10.1097/00001622-199507000-00015.

Abstract

Environmental factors, particularly pertaining to the diet, are of importance in the pathogenesis of gastrointestinal neoplasia. Increasingly sophisticated studies have begun to elucidate some of the mechanisms responsible for both the deleterious and protective effects of compounds ingested or smoked (such as tobacco). The new and developing field of chemoprevention holds great promise for the possibility of averting neoplasia by interfering with the metabolism of carcinogens, reducing their binding to the target cell, or even by suppressing the initiated cell.

MeSH terms

  • Antioxidants / therapeutic use
  • Calcium / therapeutic use
  • Colorectal Neoplasms / drug therapy
  • Colorectal Neoplasms / prevention & control
  • Dietary Fiber
  • Esophageal Neoplasms / prevention & control
  • Feeding Behavior*
  • Female
  • Flavonoids / therapeutic use
  • Gastrointestinal Neoplasms / diet therapy
  • Gastrointestinal Neoplasms / etiology
  • Gastrointestinal Neoplasms / prevention & control*
  • Humans
  • Male
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / mortality
  • Sulindac / therapeutic use
  • Vitamins / therapeutic use

Substances

  • Antioxidants
  • Dietary Fiber
  • Flavonoids
  • Vitamins
  • Sulindac
  • Calcium