Engineering thermostability: lessons from thermophilic proteins

Curr Opin Biotechnol. 1995 Aug;6(4):370-4. doi: 10.1016/0958-1669(95)80064-6.

Abstract

As several groups begin to tap the rich pickings found in the Archaea--a vast kingdom that stretches the concept of life as we know it--the structures of proteins from hyperthermophiles are being elucidated. Certain features are beginning to emerge, such as compactness and hydrophobic clustering, but the ability to engineer these features into temperature-intolerant proteins is still some way off.

Publication types

  • Review

MeSH terms

  • Amino Acids / analysis
  • Animals
  • Archaea / chemistry
  • Archaea / physiology
  • Enzyme Stability*
  • Enzymes / chemistry*
  • Hot Temperature*
  • Protein Engineering*
  • Proteins / chemistry*

Substances

  • Amino Acids
  • Enzymes
  • Proteins