Immunoreactivity for c-fos and c-myc protein with the monoclonal antibodies 14E10 and 6E10 in malignant mesothelioma and non-neoplastic mesothelium of the pleura

Histol Histopathol. 1995 Jul;10(3):639-43.


We studied immunoreactivity for c-fos protein and c-myc protein in malignant mesothelioma (36 cases) and non-neoplastic pleural mesothelium (45 cases) using the murine monoclonal antibodies 14E10 and 6E10. All malignant mesotheliomas and cases with non-neoplastic mesothelium exhibited not only nuclear but also cytoplasmic immunoreactivity for c-fos and c-myc protein in the majority of mesothelial cells. There was no statistically significant difference between the various mesothelioma subtypes or between neoplastic and non-neoplastic mesothelium for c-fos protein immunoreactivity (p > 0.05). There was statistically significant difference between neoplastic and non-neoplastic mesothelium for c-myc protein immunoreactivity (p < 0.01). We conclude that immunoreactivity for c-fos and c-myc protein is present in both non-neoplastic and neoplastic mesothelium, but that a higher proportion of neoplastic mesothelial cells are immunoreactive for c-myc protein when compared with non-neoplastic mesothelium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antibodies, Monoclonal
  • Cell Nucleus / ultrastructure
  • Cytoplasm / ultrastructure
  • Humans
  • Immunohistochemistry
  • Mesothelioma / metabolism*
  • Mesothelioma / pathology
  • Mesothelioma / ultrastructure
  • Molecular Sequence Data
  • Paraffin Embedding
  • Pleural Diseases / metabolism*
  • Pleural Diseases / pathology
  • Pleural Neoplasms / metabolism*
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / ultrastructure
  • Proto-Oncogene Proteins c-fos / metabolism*
  • Proto-Oncogene Proteins c-myc / metabolism*


  • Antibodies, Monoclonal
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-myc