Determination events in the nervous system of the vertebrate embryo

Curr Opin Genet Dev. 1995 Aug;5(4):450-8. doi: 10.1016/0959-437x(95)90048-l.


Molecular and functional data suggest that the regionalization of the caudal portion of the vertebrate embryonic brain (hindbrain) is set up through a process of segmentation. In contrast, the more rostrally located met-mesencephalic domain (mid-hindbrain junction) appears to follow a mode of specification that relies on long-range inducing and organizing activities originating from the central region of the domain. Recent studies addressing this mode of anterior/posterior determination point to Wnt-1 as a key player in this process.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System / embryology*
  • Cerebellum / embryology
  • Embryonic Induction
  • Mesencephalon / embryology*
  • Proto-Oncogene Proteins / physiology
  • Vertebrates / embryology*
  • Wnt Proteins
  • Wnt1 Protein
  • Zebrafish Proteins*


  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Wnt1 Protein
  • Zebrafish Proteins