The role of the notochord and floor plate in inductive interactions

Curr Opin Genet Dev. 1995 Aug;5(4):499-506. doi: 10.1016/0959-437x(95)90055-l.


Recent studies have uncovered new roles for the notochord and floor plate in patterning adjacent cells, elaborating their importance as essential organizers of neural and paraxial tissue. The identification of key molecules that mediate the ability of notochord and floor plate to induce cells to adopt distinct fates has provided a first step in elucidating the mechanisms underlying these events.

Publication types

  • Review

MeSH terms

  • Animals
  • Embryonic Induction / physiology*
  • Hedgehog Proteins
  • Nervous System / embryology*
  • Notochord / physiology*
  • Proteins / physiology
  • Signal Transduction / physiology
  • Trans-Activators*


  • Hedgehog Proteins
  • Proteins
  • Trans-Activators