Modulation of inhibitory synapses in the mammalian brain

Curr Opin Neurobiol. 1995 Jun;5(3):335-41. doi: 10.1016/0959-4388(95)80046-8.


Recent studies have identified new forms of short-term and long-term modulation at inhibitory synapses. In cerebellum and hippocampus, a transient inhibition of synaptic efficacy has been found to involve a Ca(2+)-dependent retrograde messenger. Exciting results from work in the visual cortex suggest that forms of both long-term potentiation and long-term depression occur in cortical inhibitory synapses.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Cerebellum / physiology*
  • Hippocampus / physiology*
  • Long-Term Potentiation / physiology
  • Synapses / physiology*
  • Visual Cortex / physiology


  • Calcium