Get receptive to metabotropic glutamate receptors

Curr Opin Neurobiol. 1995 Jun;5(3):342-9. doi: 10.1016/0959-4388(95)80047-6.


Glutamate activates not only ionotropic glutamate receptors, but also G-protein-coupled receptors, called metabotropic glutamate receptors. Recent studies have revealed that these metabotropic receptors share distinctive structural properties and that they form a subgroup within the heptahelical receptor family. The development of ligands that bind specifically to these receptors has provided a means of characterizing the important roles they play in the tuning of fast synaptic transmission, including the induction of long-term changes in synaptic strength. Their involvement in the control of movement, spatial and olfactory memory and nociception has recently been demonstrated.

Publication types

  • Review

MeSH terms

  • Animals
  • Glutamic Acid / pharmacology*
  • Molecular Structure
  • Receptors, Glutamate / classification*
  • Receptors, Glutamate / physiology*
  • Receptors, Metabotropic Glutamate / physiology*
  • Synapses / physiology


  • Receptors, Glutamate
  • Receptors, Metabotropic Glutamate
  • Glutamic Acid