Rapidly progressive frontal-type dementia associated with Lyme disease

J Neuropsychiatry Clin Neurosci. Summer 1995;7(3):345-7. doi: 10.1176/jnp.7.3.345.


The authors report a case of fatal neuropsychiatric Lyme disease (LD) that was expressed clinically by progressive frontal lobe dementia and pathologically by severe subcortical degeneration. Antibiotic treatment resulted in transient improvement, but the patient relapsed after the antibiotics were discontinued. LD must be considered even in cases with purely psychiatric presentation, and prolonged antibiotic therapy may be necessary.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Dementia / etiology*
  • Dementia / physiopathology
  • Dementia / psychology
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Lyme Disease / complications*
  • Lyme Disease / parasitology
  • Lyme Disease / psychology
  • Male
  • Psychiatric Status Rating Scales
  • Thalamus / parasitology


  • Anti-Bacterial Agents