A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity

Nat Genet. 1995 Nov;11(3):287-93. doi: 10.1038/ng1195-287.


In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for schizophrenia in region 6p24-22. The greatest lod score, assuming locus heterogeneity, is 3.51 (P = 0.0002) with D6S296. Another test, the C test, also supported linkage, the strongest results being obtained with D6S296 (P = 0.00001), D6S274 (P = 0.004) and D6S285 (P = 0.006). Non-parametric analysis yielded suggestive, but substantially weaker, findings. This locus appears to influence the vulnerability to schizophrenia in roughly 15 to 30% of our pedigrees. Evidence for linkage was maximal using an intermediate phenotypic definition and declined when this definition was narrowed or was broadened to include other psychiatric disorders.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 6*
  • Genetic Heterogeneity*
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Lod Score
  • Models, Genetic
  • Pedigree
  • Schizophrenia / diagnosis
  • Schizophrenia / genetics*


  • Genetic Markers