Detection of antiribosomal P protein antibodies in patients with systemic sclerosis

Br J Rheumatol. 1995 Oct;34(10):908-11. doi: 10.1093/rheumatology/34.10.908.


This study investigated the prevalence and clinical significance of anti-ribosomal P protein (anti-P) antibodies in patients with systemic sclerosis (SSc). Serum samples from 150 patients with SSc were examined by indirect immunofluorescence. ELISA and immunoblotting. Anti-P antibodies were detected in four (3%) patients with SSc. Three of the four patients showed SSc/SLE (systemic lupus erythematosus) overlap syndrome, but psychiatric disorders were not observed in these patients. By longitudinal immunoblotting analysis one patient, who was initially diagnosed with SSc, later developed anti-P antibodies along clinical manifestations of SLE. Our data suggest that anti-P antibodies are uncommon in SSc and that the presence of anti-P antibodies in patients with SSc indicates an overlap with SLE.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Anti-Idiotypic / blood*
  • Female
  • Humans
  • Longitudinal Studies
  • Lupus Erythematosus, Systemic / immunology
  • Protozoan Proteins*
  • Ribosomal Proteins / immunology*
  • Scleroderma, Systemic / blood
  • Scleroderma, Systemic / immunology*


  • Antibodies, Anti-Idiotypic
  • L12E protein, Trypanosoma cruzi
  • Protozoan Proteins
  • Ribosomal Proteins