Destructive lymphadenopathy and T-lymphocyte activation in adult-onset Still's disease

Br J Rheumatol. 1995 Oct;34(10):984-8. doi: 10.1093/rheumatology/34.10.984.


Recurrent arthritis, fever and lymphadenopathy are symptoms of adult onset of Still's disease (AOSD). Differential diagnosis requires the exclusion of infections or malignant lymphomas. We report on a case of AOSD showing destructive lymphadenopathy, immunophenotyping of peripheral blood leucocytes revealed strong activation of T-lymphocytes. Bone marrow biopsy also showed an increase of lymphopoietic cells to 23%. Analysis of peripheral blood lymphocytes (PBL) after remission showed no remaining signs of activation. Analysis of lymphocyte activation by flow cytometry correlated with disease activity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Lymphatic Diseases / etiology
  • Lymphatic Diseases / pathology*
  • Lymphocyte Activation
  • Still's Disease, Adult-Onset / complications*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology*