Functions of fibroblast growth factors and their receptors

A O Wilkie; G M Morriss-Kay; E Y Jones; J K Heath

doi:10.1016/s0960-9822(95)00102-3

Functions of fibroblast growth factors and their receptors

Curr Biol. 1995 May 1;5(5):500-7. doi: 10.1016/s0960-9822(95)00102-3.

Authors

A O Wilkie¹, G M Morriss-Kay, E Y Jones, J K Heath

Affiliation

¹ Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

PMID: 7583099
DOI: 10.1016/s0960-9822(95)00102-3

Abstract

Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their receptors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Animals
Fibroblast Growth Factors / chemistry
Fibroblast Growth Factors / physiology*
Humans
Ligands
Molecular Sequence Data
Mutation
Protein Conformation
Receptors, Fibroblast Growth Factor / chemistry
Receptors, Fibroblast Growth Factor / physiology*

Substances

Ligands
Receptors, Fibroblast Growth Factor
Fibroblast Growth Factors