Intracellular regulation. Rac and Bcr regulate phagocytic phoxes

Curr Biol. 1995 Jul 1;5(7):710-2. doi: 10.1016/s0960-9822(95)00140-0.

Abstract

The NADPH oxidase of phagocytes is essential for defence against invading microorganisms. The small GTpase Rac seems to be critical for the activation and deactivation of the phox proteins that make up this enzyme.

Publication types

  • Review

MeSH terms

  • Animals
  • Enzyme Activation
  • GTP-Binding Proteins / metabolism*
  • Humans
  • NADH, NADPH Oxidoreductases / metabolism*
  • NADPH Oxidases
  • Oncogene Proteins / metabolism*
  • Phagocytes / enzymology*
  • Phosphoproteins / metabolism
  • Protein-Tyrosine Kinases*
  • Proto-Oncogene Proteins c-bcr
  • Proto-Oncogene Proteins*
  • rac GTP-Binding Proteins

Substances

  • Oncogene Proteins
  • Phosphoproteins
  • Proto-Oncogene Proteins
  • NADH, NADPH Oxidoreductases
  • NADPH Oxidases
  • Protein-Tyrosine Kinases
  • BCR protein, human
  • Proto-Oncogene Proteins c-bcr
  • GTP-Binding Proteins
  • rac GTP-Binding Proteins