Proteins with leucine-rich repeats

Curr Opin Struct Biol. 1995 Jun;5(3):409-16. doi: 10.1016/0959-440x(95)80105-7.


Leucine-rich repeats are short sequence motifs present in over sixty proteins, all of which appear to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor demonstrated that the repeats correspond to beta-alpha structural units. The recently determined crystal structure of the ribonuclease A-ribonuclease inhibitor complex suggests the basis for the protein-binding function of leucine-rich repeats.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Humans
  • Leucine / chemistry*
  • Protein Binding
  • Protein Conformation
  • Proteins / chemistry*
  • Repetitive Sequences, Nucleic Acid
  • Sequence Analysis


  • Proteins
  • Leucine