Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors

J Gerontol A Biol Sci Med Sci. 1995 Nov;50(6):B378-82. doi: 10.1093/gerona/50a.6.b378.

Abstract

As a part of an ongoing longitudinal investigation, this study examined relationships between survival and selected immune system parameters in a sample (n = 102) of very old individuals (86-92 years at the time of initial immune system data collection). Analyses were performed comparing initial time-point measurements from those individuals who were alive (n = 75) and those who were deceased (n = 27) two years after initial data collection. Immune system measurements consisted of determination of peripheral blood lymphocytes and lymphocyte subsets, as well as T-cell responses to activation by Concanavalin A. Cluster analysis identified a subgroup associated with nonsurvival which indicated characteristics that included: poor T-cell proliferative responses, high CD8 percentages, and low CD4 and CD19 percentages. This multivariate analysis suggested that combinations of immune system parameters predict two-year survival otherwise not apparent when single immune system parameters were evaluated in the elderly.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / immunology*
  • Antigens, CD / analysis
  • Cell Division / drug effects
  • Cluster Analysis
  • Concanavalin A / pharmacology
  • Humans
  • Immune System / physiology*
  • Longitudinal Studies
  • Lymphocyte Count / drug effects
  • Lymphocyte Subsets / cytology
  • Retrospective Studies
  • Survival Analysis
  • Survivors
  • Sweden
  • T-Lymphocytes* / cytology
  • T-Lymphocytes* / drug effects
  • T-Lymphocytes* / immunology

Substances

  • Antigens, CD
  • Concanavalin A