Effect of nonsteroidal anti-inflammatory and other pharmacological agents on tuberculin reaction

J Pharm Sci. 1979 Jan;68(1):12-5. doi: 10.1002/jps.2600680108.


Nonsteroidal anti-inflammatory and other pharmacological agents were tested in the efferent arc of the tuberculin skin reaction in the guinea pig. A low but significant inhibition was produced by the acidic anti-inflammatory agents, including the arylalkanoic acids, the anthranilic acids, indomethacin, and phenylbutazone. Some nonacidic anti-inflammatory agents also were inhibitory; benzydamine caused a high inhibition. Except for methotrexate, the antineoplastic--antimetabolite agents were not potent inhibitors. Inhibition without toxicity was produced by the coumarin anticoagulants, the diuretics, chloroquine, tilorone, and the following immunoregulators: antithymocyte gamma-globulin, cyclophosphamide, and penicillamine. Levamisole, colchicine, heparin, and niridazole were inhibitory but produced lethality either at or above the effective dose.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Anticoagulants / pharmacology
  • Antimetabolites, Antineoplastic / pharmacology
  • Guinea Pigs
  • Histamine
  • Immunity, Cellular / drug effects*
  • Male
  • Tuberculin Test
  • Turpentine


  • Anti-Inflammatory Agents
  • Anticoagulants
  • Antimetabolites, Antineoplastic
  • Histamine
  • Turpentine