South American plants II: taspine isolation and anti-inflammatory activity

J Pharm Sci. 1979 Jan;68(1):124-6. doi: 10.1002/jps.2600680145.

Abstract

Croton lechleri L. (Euphorbiaceae), a plant from the Upper Amazon Valley of Peru, yielded the alkaloid taspine. The anti-inflammatory activity of taspine hydrochloride was studied using the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model.

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Alkaloids / toxicity
  • Animals
  • Anti-Inflammatory Agents / isolation & purification*
  • Arthritis, Experimental / physiopathology
  • Edema / physiopathology
  • Granuloma / physiopathology
  • Lethal Dose 50
  • Male
  • Methods
  • Peru
  • Plants, Medicinal / analysis*
  • Rats

Substances

  • Alkaloids
  • Anti-Inflammatory Agents
  • taspine