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Review
, 1 (1), 27-31

Angiogenesis in Cancer, Vascular, Rheumatoid and Other Disease

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Review

Angiogenesis in Cancer, Vascular, Rheumatoid and Other Disease

J Folkman. Nat Med.

Abstract

Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new paradigm of tumorigenesis. It is now helpful to think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth. The extent to which the negative regulators are decreased during this switch may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.

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