Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Nat Med. 1995 Nov;1(11):1155-61. doi: 10.1038/nm1195-1155.


Leptin, the gene product of the obese gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass. Plasma leptin was found to be highly correlated with body mass index (BMI) in rodents and in 87 lean and obese humans. In humans, there was variability in plasma leptin at each BMI suggesting that there are differences in its secretion rate from fat. Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Body Mass Index
  • Energy Intake
  • Fasting
  • Female
  • Humans
  • Immunoblotting
  • Indians, North American
  • Leptin
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mice, Obese
  • Middle Aged
  • Obesity / blood*
  • Obesity / ethnology
  • Proteins / analysis*
  • Proteins / genetics
  • RNA / genetics
  • RNA / metabolism
  • Rats
  • Rats, Mutant Strains
  • Weight Loss
  • White People


  • Leptin
  • Proteins
  • RNA