An FGF Receptor Signaling Pathway Is Required for the Normal Cell Migrations of the Sex Myoblasts in C. Elegans Hermaphrodites

Cell. 1995 Nov 17;83(4):611-20. doi: 10.1016/0092-8674(95)90101-9.

Abstract

The sex myoblasts (SMs) in C. elegans hermaphrodites undergo anteriorly directed cell migrations that allow for the proper localization of the egg-laying muscles. These migrations are controlled in part by a signal emanating from gonadal cells that allows the SMs to be attracted to their precise final positions flanking the center of the gonad. Mutations in egl-15 alter the nature of the interaction between the gonad and the SMs, resulting in the posterior displacement of the SMs. Here we show that egl-15 encodes a receptor tyrosine kinase of the fibroblast growth factor receptor (FGFR) subfamily with multiple roles in development. Three genes were identified that behave genetically as activators or mediators of egl-15 activity. One of these genes, sem-5, encodes an adaptor molecule that transduces signals from a variety of receptor tyrosine kinases. Like egl-15 and sem-5, the other two genes may similarly act in FGFR signaling pathways in C. elegans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis / cytology*
  • Cell Movement / physiology
  • Disorders of Sex Development / physiopathology
  • Genes, Helminth / physiology
  • Molecular Sequence Data
  • Muscles / cytology*
  • Muscles / physiology
  • Protein-Tyrosine Kinases / genetics
  • Receptors, Fibroblast Growth Factor / genetics*
  • Sex Factors
  • Signal Transduction / physiology*
  • Suppression, Genetic

Substances

  • Receptors, Fibroblast Growth Factor
  • Protein-Tyrosine Kinases

Associated data

  • GENBANK/U39761