Long-term follow-up of low-dose methotrexate therapy in one case of idiopathic retroperitoneal fibrosis

Clin Rheumatol. 1995 Jul;14(4):481-4. doi: 10.1007/BF02207688.


Idiopathic retroperitoneal fibrosis (RPF) is characterized by the development of a fibrotic mass surrounding the abdominal aorta and its branches, of unknown aetiology. Several immunological mechanisms can be operative in the pathogenesis of RPF. Based on this assumption we treated a patient affected by idiopathic RPF with low-dose methotrexate (MTX) therapy. To our knowledge this is the first example of the effectiveness and safety of a long-term low-dose MTX treatment in the post-surgical management of RPF.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Administration Schedule
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Methotrexate / administration & dosage
  • Methotrexate / therapeutic use*
  • Retroperitoneal Fibrosis / diagnostic imaging
  • Retroperitoneal Fibrosis / drug therapy*
  • Retroperitoneal Fibrosis / surgery
  • Tomography, X-Ray Computed


  • Immunosuppressive Agents
  • Methotrexate