Acute lung disease in the immunocompromised host. Diagnostic accuracy of the chest radiograph

Chest. 1995 Nov;108(5):1283-7. doi: 10.1378/chest.108.5.1283.

Abstract

Purpose: To assess the diagnostic accuracy of the chest radiograph in the evaluation of acute pulmonary complications in immunocompromised patients.

Methods: The study included the chest radiographs in 149 consecutive acute pulmonary complications seen in immunocompromised patients in whom a definitive diagnosis was made. Twenty-four complications were in patients with AIDS and 125 were in non-AIDS patients. The radiographs were separately reviewed in random order by two independent observers. The observers assessed pattern and distribution of radiographic findings and recorded their first-choice diagnosis.

Results: The most common complication in patients with AIDS was Pneumocystis carinii pneumonia (n = 21). In the non-AIDS patients, the most common complications included invasive aspergillosis (n = 25), drug reaction (n = 21), and Pneumocystis pneumonia (n = 20). A correct first-choice diagnosis was made in 90% of patients with AIDS and 34% of non-AIDS patients. IN AIDS patients with Pneumocystis pneumonia, the correct first-choice diagnosis was made in 41 of 42 (98%) readings by the two observers. In non-AIDS patients with invasive pulmonary aspergillosis, drug reaction, and Pneumocystis pneumonia, the correct first-choice diagnosis was made in 38%, 26%, and 43% of readings, respectively.

Conclusion: The chest radiograph is helpful in the differential diagnosis of acute lung disease in the immunocompromised host, particularly in patients with AIDS.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Immunocompromised Host*
  • Lung Diseases / complications
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / immunology
  • Male
  • Middle Aged
  • Pneumonia, Pneumocystis / complications
  • Pneumonia, Pneumocystis / diagnostic imaging
  • Predictive Value of Tests
  • Radiography