Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide

Eur J Pharmacol. 1995 May 24;278(3):279-83. doi: 10.1016/0014-2999(95)00181-j.


In anaesthetised rats, the endogenous cannabinoid anandamide has potent cardiovascular effects that include a brief pressor effect and a more prolonged depressor response. The depressor response is attenuated after transection of the cervical spinal cord or blockade of alpha-adrenergic receptors by phentolamine, and is dose-dependently inhibited by a selective antagonist of the CB1 cannabinoid receptor. The pressor component is not affected by any of these interventions. This suggests that the depressor response is due to inhibition of sympathetic tone mediated by CB1 receptors, whereas the pressor component is due to a peripheral action that does not involve the same receptors or the sympathetic nervous system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anesthesia
  • Animals
  • Arachidonic Acids / pharmacology*
  • Blood Pressure / drug effects*
  • Calcium Channel Blockers / pharmacology*
  • Endocannabinoids
  • Heart Rate / drug effects
  • Male
  • Piperidines / pharmacology
  • Polyunsaturated Alkamides
  • Pyrazoles / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cannabinoid
  • Receptors, Drug / antagonists & inhibitors*
  • Rimonabant
  • Urethane


  • Arachidonic Acids
  • Calcium Channel Blockers
  • Endocannabinoids
  • Piperidines
  • Polyunsaturated Alkamides
  • Pyrazoles
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Urethane
  • Rimonabant
  • anandamide