The biochemical effects of clenbuterol: with particular reference to taurine and muscle damage

Eur J Pharmacol. 1995 Jul 1;293(2):141-9. doi: 10.1016/0926-6917(95)00010-0.

Abstract

Administration of clenbuterol to rats in the drinking water over a 4 day period increased incorporation of [3H]leucine into muscle protein and caused a slight reduction in urinary 3-methylhistidine but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 mg.kg-1.day-1). Serum creatine kinase, muscle isoenzyme (CK-MM) was raised and single muscle fibre injury was observed in the soleus muscle in animals treated with the middle dose (0.2 mg.kg-1.day-1) and highest dose (2 mg.kg-1.day-1). The reduction in the body pool of taurine caused by clenbuterol is of concern as taurine has been shown to have protective properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Agonists / toxicity*
  • Animals
  • Clenbuterol / toxicity*
  • Creatine / urine
  • Creatinine / urine
  • Enzymes / blood
  • Leucine / metabolism
  • Liver Glycogen / metabolism
  • Male
  • Methylhistidines / urine
  • Muscle Fibers, Skeletal / drug effects
  • Muscle Proteins / biosynthesis
  • Muscles / drug effects*
  • Muscles / metabolism
  • Muscles / pathology
  • Organ Size / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Sulfhydryl Compounds / blood
  • Taurine / metabolism*
  • Taurine / urine

Substances

  • Adrenergic beta-Agonists
  • Enzymes
  • Liver Glycogen
  • Methylhistidines
  • Muscle Proteins
  • Sulfhydryl Compounds
  • Taurine
  • Creatinine
  • Leucine
  • 3-methylhistidine
  • Creatine
  • Clenbuterol