Does Vav bind to F-actin through a CH domain?

FEBS Lett. 1995 Oct 30;374(2):149-51. doi: 10.1016/0014-5793(95)01098-y.


An actin-binding protein domain we call here 'calponin-homology' or CH is present in signalling proteins such as Vav which are involved in activation and inactivation of small G-proteins. Using profile methods, we have detected two repeats of this domain in the actin-binding region of alpha-actinin and related proteins. Based on this, we propose that CH domain in Vav and other signalling proteins is employed for association with filamentous actin, and that this function correlates with their control on the G-proteins Rac and Rho which are involved in the organization of cytoskeleton.

MeSH terms

  • Actins / metabolism*
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Cell Cycle Proteins*
  • Humans
  • Microfilament Proteins / chemistry
  • Microfilament Proteins / metabolism*
  • Molecular Sequence Data
  • Protein Binding
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-vav
  • Sequence Homology, Amino Acid


  • Actins
  • Carrier Proteins
  • Cell Cycle Proteins
  • F-actin-binding proteins
  • Microfilament Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-vav
  • VAV1 protein, human