Parasympatholytic activity of psychoactive drugs in rat brain mitochondria

Indian J Exp Biol. 1995 Jun;33(6):462-3.

Abstract

Chlorpromazine, imipramine and amphetamine at a concentration of 0.66, 1.33 and 13.3 x 10(4) M in vitro inhibited acetyl cholinesterase activity by 16, 23 and 31% respectively in rat brain mitochondria. No change in enzyme activity was induced by these drugs in vivo. There is little cholinergic facilitation through acetylcholinesterase inhibition in the presence of psychoactive drugs.

Publication types

  • Comparative Study

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Amphetamine / pharmacology
  • Animals
  • Brain / enzymology*
  • Chlorpromazine / pharmacology
  • Cholinesterase Inhibitors / pharmacology*
  • Imipramine / pharmacology
  • Lithium Chloride / pharmacology
  • Male
  • Mitochondria / drug effects
  • Mitochondria / enzymology*
  • Parasympatholytics / pharmacology*
  • Psychotropic Drugs / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Cholinesterase Inhibitors
  • Parasympatholytics
  • Psychotropic Drugs
  • Amphetamine
  • Acetylcholinesterase
  • Lithium Chloride
  • Imipramine
  • Chlorpromazine