Expression of MAGE Genes in Primary and Metastatic Cutaneous Melanoma

Int J Cancer. 1995 Nov 3;63(3):375-80. doi: 10.1002/ijc.2910630313.

Abstract

Human genes MAGE-1 and MAGE-3 code for antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. These antigens may constitute useful targets for specific anti-tumor immunization of cancer patients, since genes MAGE-1 and MAGE-3 are expressed in a number of tumors of different histological types, but are not expressed in normal adult tissues other than testis. This also applies to genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3. We have analyzed the expression of these 4 MAGE genes in cutaneous melanoma. Sixteen of 100 primary tumors vs. 69 (48%) of 145 metastases from individual patients expressed MAGE-1. Similar differences in the frequency of gene expression between primary and metastatic tumor samples were observed for MAGE-2, MAGE-3, and MAGE-4. MAGE expression in primary tumors was correlated with tumor thickness: there was a significantly increased frequency in the expression of MAGE-1, -2 and -3 in tumors of greater thickness. Benign and dysplastic nevi, as well as in situ melanomas, did not express any of the 4 MAGE genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, Neoplasm / genetics*
  • Base Sequence
  • Gene Expression
  • Humans
  • Melanoma / genetics*
  • Melanoma / pathology
  • Melanoma / secondary
  • Melanoma-Specific Antigens
  • Molecular Sequence Data
  • Neoplasm Proteins*
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology

Substances

  • Antigens, Neoplasm
  • MAGEA1 protein, human
  • MAGEA3 protein, human
  • MAGEB2 protein, human
  • Melanoma-Specific Antigens
  • Neoplasm Proteins