Microsatellite instability in oral cancer

Int J Cancer. 1995 Oct 20;64(5):332-5. doi: 10.1002/ijc.2910640509.


Generalized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the somatic loss of DNA mismatch repair capability. Germ-line mutations at DNA mismatch repair loci confer susceptibility to colon cancer in hereditary non-polyposis colorectal cancer. Somatic loss of DNA mismatch repair has been reported in a large variety of other tumor types. Our goal was to determine the frequency of microsatellite instability in a large series of oral tumors. Out of 91 tumors analyzed for microsatellite instability, 6 (7%) showed microsatellite instability. Instability was observed at multiple loci with a range of 50-74% of loci affected. Alterations include both increase (74%) and decrease (26%) in allele sizes. The proportion of alleles affected ranged from 30-58% of all alleles. Our data suggest that somatic genomic instability plays a role in the pathogenesis of a small subset of oral tumors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Carcinoma, Squamous Cell / blood
  • Carcinoma, Squamous Cell / genetics*
  • Chromosomes, Human
  • DNA Repair
  • DNA Replication
  • DNA, Neoplasm / genetics*
  • DNA, Satellite / genetics*
  • Genetic Markers
  • Humans
  • Lymphocytes / ultrastructure
  • Middle Aged
  • Mouth Neoplasms / blood
  • Mouth Neoplasms / genetics*


  • DNA, Neoplasm
  • DNA, Satellite
  • Genetic Markers