Bone formation utilizing titanium-reinforced barrier membranes

Int J Periodontics Restorative Dent. 1995 Feb;15(1):56-69.


Advances in bone reconstructive techniques have increased the indications for implant placement in sites previously thought to be unsuitable. This clinical study evaluated a new surgical technique for the treatment of a variety of localized bone defects in four patients utilizing a titanium-reinforced membrane. The membrane material was developed to maintain a large protected space between the membrane and the bone surface without the need for a supportive device. Healing was uneventful in all sites, and the membranes were retrieved after 6 to 12 months. No residual defects were noted, resulting in an average change of implant exposure of 8.2 +/- 2.3 mm for sites with buccal dehiscences and from 5 to 6 mm ridge enlargement in localized bone defects. The quality of the regenerated tissue under the titanium-reinforced membrane appeared as bone structure with a superficial fibrous layer. This fibrous layer was more pronounced in sites treated with a membrane alone but was more than compensated by the quantity of new bone under the soft tissue. The results demonstrated that the use of a reinforced membrane appears to be a viable alternative for the clinical treatment of non-space-maintaining implant/bone defects. Further clinical and experimental investigations are recommended.

MeSH terms

  • Adult
  • Alveolar Bone Loss / surgery*
  • Bone Regeneration*
  • Bone Transplantation / methods
  • Dental Implantation, Endosseous
  • Dental Implants
  • Guided Tissue Regeneration, Periodontal*
  • Humans
  • Membranes, Artificial
  • Polytetrafluoroethylene
  • Surgical Flaps
  • Titanium*


  • Dental Implants
  • Membranes, Artificial
  • Polytetrafluoroethylene
  • Titanium