The role of arginine, indomethacin and kallikrein in the treatment of oligoasthenospermia

Int Urol Nephrol. 1995;27(2):199-202. doi: 10.1007/BF02551320.


We have treated 45 patients with various degrees of oligospermia and asthenospermia with arginine, indomethacin and kallikrein. Fifteen patients have received the amino acid L-arginine hydrochloride, 15 the antiinflammatory agent indomethacin, while 15 others the enzyme kallikrein. These drugs have been administered for at least 3 months to encompass a complete cycle of spermatogenesis. As a result, treatment with these drugs has increased sperm count and motility to some extent. Three pregnancies (20%) have been obtained by arginine and one pregnancy (6.6%) by indomethacin. Though arginine offers some hope for the future, improvement of the fertilizing capacity with these drugs is still controversial.

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arginine / therapeutic use*
  • Drug Therapy, Combination
  • Humans
  • Indomethacin / therapeutic use*
  • Kallikreins / therapeutic use*
  • Male
  • Oligospermia / drug therapy*
  • Sperm Count / drug effects
  • Sperm Motility / drug effects
  • Treatment Outcome


  • Anti-Inflammatory Agents, Non-Steroidal
  • Arginine
  • Kallikreins
  • Indomethacin