Structure determination of MS-444; a new myosin light chain kinase inhibitor

Y Aotani; Y Saitoh

doi:10.7164/antibiotics.48.952

Structure determination of MS-444; a new myosin light chain kinase inhibitor

J Antibiot (Tokyo). 1995 Sep;48(9):952-3. doi: 10.7164/antibiotics.48.952.

Authors

Y Aotani¹, Y Saitoh

Affiliation

¹ Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.

PMID: 7592061
DOI: 10.7164/antibiotics.48.952

Abstract

MS-444 is a novel myosin light chain kinase inhibitor, isolated from the culture broth of Micromonospora sp. KY7123. The structure of MS-444 was determined to be 5,8-dihydroxy-3-methyl-(9H)-naphtho[2,3-c]furan-4-one by means of spectral analysis.

MeSH terms

Furans / chemistry*
Furans / pharmacology
Molecular Structure
Myosin-Light-Chain Kinase / antagonists & inhibitors*
Naphthols / chemistry*
Naphthols / pharmacology
Spectrum Analysis

Substances

Furans
Naphthols
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone
Myosin-Light-Chain Kinase