A novel serum protein similar to C1q, produced exclusively in adipocytes

J Biol Chem. 1995 Nov 10;270(45):26746-9. doi: 10.1074/jbc.270.45.26746.


We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation-specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum protein. Acrp30 may be a factor that participates in the delicately balanced system of energy homeostasis involving food intake and carbohydrate and lipid catabolism. Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Adiponectin
  • Adipose Tissue / metabolism*
  • Amino Acid Sequence
  • Animals
  • Blood Proteins / biosynthesis*
  • Blood Proteins / chemistry
  • Blood Proteins / genetics
  • Cloning, Molecular
  • Complement C1q / biosynthesis*
  • Complement C1q / chemistry
  • Complement C1q / genetics
  • Insulin / metabolism
  • Intercellular Signaling Peptides and Proteins*
  • Mice
  • Molecular Sequence Data
  • Molecular Structure
  • Molecular Weight
  • Proteins*
  • Repetitive Sequences, Nucleic Acid


  • Adiponectin
  • Blood Proteins
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • Complement C1q