Interferon-gamma and tumor necrosis factor-alpha protect mice from invasive aspergillosis

J Infect Dis. 1995 Dec;172(6):1554-60. doi: 10.1093/infdis/172.6.1554.


The immunopathogenesis of invasive aspergillosis and the role played by cytokines are not fully understood. The roles of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha were investigated in BALB/c mice infected intravenously with 5 x 10(5) Aspergillus fumigatus conidia. Eight groups of animals were studied, including 2 control groups (mice only infected with A. fumigatus and those given cortisone acetate and infected with A. fumigatus) and 6 groups of infected mice either treated or not treated with cortisone acetate and given IFN-gamma, anti-IFN-gamma, TNF-alpha, or anti-TNF-alpha. No deaths occurred among the mice treated with IFN-gamma and TNF-alpha, compared with 40%-80% mortality in the other groups. IFN-gamma- and TNF-alpha-treated mice also had fewer organs from which A. fumigatus could be cultured or demonstrated on histologic examination. These observations suggest that IFN-gamma and TNF-alpha have protective roles in invasive aspergillosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Aspergillosis / prevention & control*
  • Cortisone / pharmacology
  • Cytokines / genetics
  • Female
  • Interferon-gamma / pharmacology
  • Interferon-gamma / physiology*
  • Mice
  • Mice, Inbred BALB C
  • RNA, Messenger / analysis
  • Recombinant Proteins
  • Tumor Necrosis Factor-alpha / pharmacology
  • Tumor Necrosis Factor-alpha / physiology*


  • Cytokines
  • RNA, Messenger
  • Recombinant Proteins
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma
  • Cortisone