Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma

S C Formenti; L Chak; P Gill; E M Buess; C K Hill

doi:10.1080/09553009514551361

Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma

Int J Radiat Biol. 1995 Oct;68(4):411-2. doi: 10.1080/09553009514551361.

Authors

S C Formenti¹, L Chak, P Gill, E M Buess, C K Hill

Affiliation

¹ Department of Radiation Oncology, University of Southern California School of Medicine, Los Angeles 90033, USA.

PMID: 7594966
DOI: 10.1080/09553009514551361

Abstract

Fibroblasts cultured from skin biopsies of patients with AIDS and Kaposi's sarcoma were found to be more radiosensitive than fibroblasts from non-HIV-infected-sources. This supports clinical observations of overt sensitivity to radiotherapy in some AIDS patients with Kaposi's sarcoma.

MeSH terms

Acquired Immunodeficiency Syndrome / immunology*
Cells, Cultured
Fibroblasts / radiation effects
Humans
Radiation Tolerance*
Sarcoma, Kaposi / radiotherapy*