Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma

Int J Radiat Biol. 1995 Oct;68(4):411-2. doi: 10.1080/09553009514551361.


Fibroblasts cultured from skin biopsies of patients with AIDS and Kaposi's sarcoma were found to be more radiosensitive than fibroblasts from non-HIV-infected-sources. This supports clinical observations of overt sensitivity to radiotherapy in some AIDS patients with Kaposi's sarcoma.

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Cells, Cultured
  • Fibroblasts / radiation effects
  • Humans
  • Radiation Tolerance*
  • Sarcoma, Kaposi / radiotherapy*