Allopurinol reduces the severity of peritoneal adhesions in mice

J Pediatr Surg. 1995 Apr;30(4):533-7. doi: 10.1016/0022-3468(95)90124-8.

Abstract

A study was designed to investigate the possibility of reducing peritoneal adhesion formation in mice by pretreatment with allopurinol. Allopurinol, at a dose of 35 mg/kg of body weight/d significantly reduced the severity of peritoneal adhesions (P < .001), and also the neutrophil response to ischemia (P < .05). Tissue myeloperoxidase activity at the site of ischemic injury was significantly lower in the allopurinol-treated mice at the end of 2 weeks (P < .001). However, xanthine oxidase was undetectable in both control and allopurinol-treated mice. These observations suggest that allopurinol reduces the severity of peritoneal adhesion formation in mice, possibly by reducing the neutrophil response to ischemia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allopurinol / administration & dosage
  • Allopurinol / therapeutic use*
  • Animals
  • Laparotomy
  • Male
  • Malondialdehyde / metabolism
  • Mice
  • Neutrophils / drug effects
  • Neutrophils / physiology
  • Peritoneal Diseases / prevention & control*
  • Peritoneum / enzymology
  • Peroxidase / metabolism
  • Pilot Projects
  • Postoperative Complications / prevention & control
  • Premedication
  • Reperfusion Injury / prevention & control*
  • Tissue Adhesions / prevention & control
  • Xanthine Oxidase / metabolism

Substances

  • Malondialdehyde
  • Allopurinol
  • Peroxidase
  • Xanthine Oxidase