Skin cancer and warts in immunosuppressed renal transplant recipients

Recent Results Cancer Res. 1995;139:69-86. doi: 10.1007/978-3-642-78771-3_6.

Abstract

Non-melanoma skin cancer (NMSC) is increasingly recognised as a complication of long-term immunosuppression and has been particularly studied in renal transplant recipients (RTR). A population study of renal transplant recipients has been performed with analysis of those features contributing to a high rate of detection of NMSC, such that 40% patients with fair skin have NMSC 5 years after transplantation. 90% of the total patient population have warts 5 years after transplantation, many being atypical and in sun-exposed sites. Therefore, contributory factors in these patients include not only the global immunosuppression, ultraviolet radiation (UVR)-induced mutagenesis and photoimmunosuppression, but also the widespread presence of human papillomavirus (HPV) infection, including the unusual epidermodysplasia verruciformis (EV)-associated cutaneous oncogenic HPV.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Carcinoma in Situ / epidemiology
  • Carcinoma in Situ / etiology
  • Carcinoma in Situ / immunology
  • Carcinoma in Situ / therapy
  • Carcinoma in Situ / virology
  • Carcinoma, Basal Cell / epidemiology
  • Carcinoma, Basal Cell / etiology*
  • Carcinoma, Basal Cell / pathology
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / etiology*
  • Carcinoma, Squamous Cell / pathology
  • Cocarcinogenesis*
  • Epidermis / pathology
  • Epidermis / radiation effects
  • Female
  • Follow-Up Studies
  • Genital Neoplasms, Female / epidemiology
  • Genital Neoplasms, Female / etiology
  • Genital Neoplasms, Male / epidemiology
  • Genital Neoplasms, Male / etiology
  • Humans
  • Immunocompromised Host
  • Immunosuppression / adverse effects*
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Leukoplakia, Oral / complications
  • Leukoplakia, Oral / epidemiology
  • Male
  • Middle Aged
  • Mouth Neoplasms / epidemiology
  • Mouth Neoplasms / etiology
  • Neoplasms, Radiation-Induced / epidemiology
  • Neoplasms, Radiation-Induced / etiology
  • Neoplasms, Radiation-Induced / pathology
  • Occupational Exposure
  • Papillomaviridae / isolation & purification
  • Papillomaviridae / pathogenicity*
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / epidemiology
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology*
  • Postoperative Complications / pathology
  • Prevalence
  • Risk Factors
  • Skin Diseases / epidemiology
  • Skin Diseases / etiology*
  • Skin Diseases / pathology
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / pathology
  • Sunlight / adverse effects
  • Tumor Virus Infections / complications*
  • Tumor Virus Infections / epidemiology
  • Ultraviolet Rays / adverse effects
  • Warts / epidemiology
  • Warts / etiology*
  • Warts / pathology